Kodein er et opioid som finnes naturlig i opiumsplanten. Fordi Paralgin forte inneholder kodein, er det et sterkere medikament en Paracet og tilsvarende legemidler. I medisinsk sammenheng brukes kodein til behandling av tørrhoste i tillegg til smertebehandling.
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Codeine is secreted into human milk. The maternal usage of codeine can probably lead to critical adverse reactions, such as Demise, in nursing infants .
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Pga. at termen/symptomet anoreksi ofte brukes som kortform for anorexia nervosa er det viktig å skille mellom disse to ulike begrepene slik at misforståelser ikke oppstår.
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Codeine can be an opioid analgesic utilized to deal with moderate to serious agony when the usage of an opioid is indicated.
Overdose and liver toxicity Acetaminophen overdose might be manifested by renal tubular necrosis, hypoglycemic coma, and thrombocytopenia. From time to time, liver necrosis can manifest along with liver failure.
Induksjon av metabolismen av paracetamol i lever, både til inaktive metabolitter og til den levertoksiske metabolitten NAPQI.
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Perfenazin hemmer omdannelsen fra kodein til den aktive metabolitten morfin via CYP2D6 og vil dermed kunne gi nedsatt analgetisk effekt av kodein.
Induksjon av metabolismen av paracetamol i lever, både til inaktive metabolitter og til den levertoksiske metabolitten NAPQI.
. The antipyretic actions of acetaminophen are likely attributed to direct motion on heat-regulating centers in the brain, causing peripheral vasodilation, sweating, and loss of system heat. The exact system of motion of the drug isn't thoroughly recognized at this time, but foreseeable future investigate could lead to deeper expertise. Codeine is often a selective agonist with the mu opioid receptor, but which has a much weaker affinity to this receptor than morphine, a far more powerful opioid drug.
Effekten av kodein kommer i all hovedsak ved at det omdannes til morfin i kroppen. Vanligvis omdannes ca. ten % av kodeindosen til morfin. Hvor stor del av kodeinet som omdannes, varierer fra particular person til person. Derfor kan det være en del variasjon i hvor sterkt folks reagerer på Paralgin forte.